7 183 081

7,183,081 Title:

Human Ck.beta.-10 polynucleotides

Abstract:

Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.

Claims:

What is claimed is:

1. An isolated nucleic acid molecule comprising a polynucleotide selected from the group consisting of: (a) a polynucleotide encoding amino acid residues 24 to 98 of SEQ IDNO: 4; and (b) a polynucleotide encoding amino acid residues 1 to 98 of SEQ ID NO: 4.

2. The isolated nucleic acid molecule of claim 1, wherein said polynucleotide is (a).

3. The isolated nucleic acid molecule of claim 1, wherein said polynucleotide is (b).

4. A vector comprising the isolated nucleic acid molecule of claim 1.

5. The vector of claim 4 wherein the nucleic acid molecule is operably associated with a heterologous regulatory sequence that controls gene expression.

6. An isolated recombinant host cell comprising the isolated nucleic acid molecule of claim 1.

7. The isolated recombinant host cell of claim 6 wherein the nucleic acid molecule is operably associated with a heterologous regulatory sequence that controls gene expression.

8. A method for producing a polypeptide, comprising: (a) culturing the isolated recombinant host cell of claim 6 under conditions suitable to produce the polypeptide encoded by said polynucleotide; and recovering the polypeptide from the cellculture.