7 125 428

7,125,428 Title:

1,3-Dihydroxybenzene derivatives and colorants containing said compounds

Abstract:

1,3-Dihydroxybenzene derivatives of general formula (I) or (Ia) or physiologically tolerated, water-soluble salts thereof ##STR00001## wherein R'1 denotes a substituted pyridyl group, a pyrimidyl group, a group of formula (IIa) or (IIIa) ##STR00002## and the dyeing agents for keratin fibers containing these compounds.

Claims:

The invention claimed is:

1. A 1,3-Dihydroxy-4-heteroarylbenzene derivative of formula (I), or a physiologically tolerated, water-soluble salt thereof: ##STR00008## wherein X denotes oxygen,sulfur or N--R5; R1 and R2 are equal or different and, independently of each other, denote hydrogen, a halogen atom, a hydroxyl group, a C.sub.1 C.sub.4-alkoxy group, a C.sub.1 C.sub.4-hydroxyalkoxy group, a C.sub.1 C.sub.6-alkyl group, a C.sub.1C.sub.4-alkylthioether group, a trifluoromethyl group, a --Si(CH.sub.3).sub.3 group, a C.sub.1 C.sub.4-hydroxyalkyl group or a C.sub.2 C.sub.4-dihydroxyalkyl group; R3 and R4 are equal or different and, independently of each other, denote hydrogen, ahydroxyl group, a halogen atom, a cyano group, a C.sub.1 C.sub.4-alkoxy group, a C.sub.1 C.sub.6-alkyl group, a C.sub.1 C.sub.4-alkylthioether group, a mercapto group, a nitro group, an amino group, a C.sub.1 C.sub.4-alkylamino group, a di(C.sub.1C.sub.4)alkylamino group, a --C(O)H group, a --C(O)CH.sub.3 group, a --C(O)CF.sub.3 group, a --Si(CH.sub.3).sub.3 group, a C.sub.1 C.sub.4-hydroxyalkyl group or a C.sub.2 C.sub.4-dihydroxyalkyl group; and R5 denotes hydrogen, a C.sub.1 C.sub.6-alkylgroup, a C.sub.2 C.sub.4-hydroxyalkyl group, a phenyl group or an acetyl group; with the proviso that at least one of R1 to R4 is not hydrogen when X denotes oxygen.

2. The 1,3-Dihydroxy-4-heteroarylbenzene derivative as defined in claim 1, wherein (i) at least one of R1, R2, R3 and R4 denote hydrogen and X denotes sulfur or oxygen or (ii) R1 and R2 simultaneously denote hydrogen and X denotes sulfur.

3. The 1,3-Dihydroxy-4-heteroarylbenzene derivative as defined in claim 1, which is selected from the group consisting of 1,3-dihydroxy-4-(thiophen-2-yl)-benzene, 1,3-dihydroxy-4-(5-nitrothiophen-2-yl)benzene,1,3-dihydroxy-4-(3-methylthiophen-2-yl)benzene and the physiologically tolerated salts thereof.

4. A 1,3-Dihydroxybenzene derivative of formula (Ia), or a physiologically tolerated, water-soluble salt thereof: ##STR00009## wherein R'1 denotes a substituted pyridyl group, a pyrimidyl group, a group of formula (IIa): ##STR00010## or a groupof formula (IIIa): ##STR00011## wherein R'2, R'3, R'4, R'5 and R'6, independently of each other, denote hydrogen, a halogen atom, a cyano group, a hydroxyl group, a C.sub.1 C.sub.4-alkoxy group, a C.sub.1 C.sub.4-hydroxyalkoxy group, a C.sub.1C.sub.6-alkyl group, a C.sub.1 C.sub.4-alkylthioether group, a mercapto group, a nitro group, an amino group, a C.sub.1 C.sub.4-alkylamino group, a hydroxy-(C.sub.1 C.sub.4)alkylamino group, a di(C.sub.1 C.sub.4)alkylamino group, a di[hydroxy(C.sub.1C.sub.4)-alkyl]amino group, a dihydroxy-(C.sub.3 C.sub.4->alkylamino group, a [hydroxy-(C.sub.1 C.sub.4)alkyl]-C.sub.1 C.sub.4-alkylamino group, a trifluoromethyl group, a --C(O)H group, a --C(O)CH.sub.3 group, a --C(O)CF.sub.3 group, a--Si(CH.sub.3).sub.3 group, a C.sub.1 C.sub.4-hydroxyalkyl group or a C.sub.2 C.sub.4-dihydroxyalkyl group, or two adjacent R'2 to R'6 groups form an --O--CH.sub.2--O-- bridge; X'1 denotes sulfur, nitrogen, oxygen, C--R'9 or N--R'8; X'2 denotes sulfur,nitrogen, oxygen, C--R'10 or N--R'8; X'3 denotes sulfur, nitrogen, oxygen, C--R'11 or N--R'8; R'7, R'9, R'10 and R'11, independently of each other, denote hydrogen, a halogen atom, a cyano group, a C.sub.1 C.sub.4-alkoxy group, a C.sub.1 C.sub.6-alkylgroup, a C.sub.1 C.sub.4-alkylthioether group, a mercapto group, a nitro group, an amino group, a C.sub.1 C.sub.4-alkylamino group, a di(C.sub.1 C.sub.4)-alkylamino group, a di(C.sub.1 C.sub.4-hydroxyalkyl)amino group, a C.sub.1 C.sub.4-hydroxyalkylaminogroup, a trifluoromethyl group, a --C(O)CH.sub.3 group, a --C(O)CF.sub.3 group, an --Si(CH.sub.3).sub.3 group, a C.sub.1 C.sub.4-hydroxyalkyl group or a C.sub.3 C.sub.4-dihydroxyalkyl group; and R'8 denotes hydrogen, a C.sub.1 C.sub.6-alkyl group, aC.sub.2 C.sub.4-hydroxyalkyl group, a phenyl group or an acetyl group, provided that at least one and at the most two of the X'1 to X'3 groups denote CR'9, C--R'10 or C--R'11 and at the most one of the X'1 to X'3 groups denotes sulfur, oxygen or N--R'8,and R'1 does not stand for a phenyl group or hydroxyphenyl group and provided that, when R'1 is the group of the formula IIIa, X'2 is not oxygen when X'1 and X'3 are CH and R'7 is hydrogen and also X'1 is not oxygen when X'2 and X'3 are CH and R'7 ishydrogen.

5. A composition for oxidative dyeing of keratin fibers containing a combination of developer substance and coupler substance, wherein said coupler substance comprises at least one 1,3-dihydroxy-4-heteroarylbenzene derivative of formula (I), ora physiologically tolerated, water-soluble salt thereof: ##STR00012## wherein X denotes oxygen, sulfur or N--R5; R1 and R2 are equal or different and, independently of each other, denote hydrogen, a halogen atom, a hydroxyl group, a C.sub.1C.sub.4-alkoxy group, a C.sub.1 C.sub.4-hydroxyalkoxy group, a C.sub.1 C.sub.6-alkyl group, a C.sub.1 C.sub.4-alkylthioether group, a trifluoromethyl group, a --Si(CH.sub.3).sub.3 group, a C.sub.1 C.sub.4-hydroxyalkyl group or a C.sub.2C.sub.4-dihydroxyalkyl group; R3 and R4 are equal or different and, independently of each other, denote hydrogen, a hydroxyl group, a halogen atom, a cyano group, a C.sub.1 C.sub.4-alkoxy group, a C.sub.1 C.sub.8-alkyl group, a C.sub.1C.sub.4-alkylthioether group, a mercapto group, a nitro group, an amino group, a C.sub.1 C.sub.4-alkylamino group, a di(C.sub.1 C.sub.4)alkylamino group, a --C(O)H group, a --C(O)CH.sub.3 group, a --C(O)CF.sub.3 group, a di(CH.sub.3).sub.3 group, aC.sub.1 C.sub.4-hydroxyalkyl group or a C.sub.2 C.sub.4-dihydroxyalkyl group; and R5 denotes hydrogen, a C.sub.1 C.sub.6-alkyl group, a C.sub.2 C.sub.4-hydroxyalkyl group, a phenyl group or an acetyl group.

6. The 1,3-Dihydroxy-4-heteroarylbenzene derivative as defined in claim 5, wherein (i) at least one of R1, R2, R3 and R4 denote hydrogen and X denotes sulfur or oxygen or (ii) R1 and R2 simultaneously denote hydrogen and X denotes sulfur.

7. The 1,3-Dihydroxy-4-heteroarylbenzene derivative as defined in claim 5, which is selected from the group consisting of 1,3-dihydroxy-4-(thiophen-2-yl)-benzene, 1,3-dihydroxy-4-(5-nitrothiophen-2-yl)benzene,1,3-dihydroxy-4-(3-methylthiophen-2-yl)benzene and 1,3-dihydroxy-4-(furan-2-yl)-benzene.

8. The composition as defined in claim 5, containing from 0.005 to 20 wt. % of said at least one 1,3-dihydroxy-4-heteroarylbenzene derivative.

9. The composition as defined in claim 5, wherein said developer substance is selected from the group consisting of 1,4-diaminobenzene; 1,4-diamino-2-methylbenzene; 1,4-diamino-2,6-dimethylbenzene; 1,4-diamino-3,5-diethylbenzene; 1,4-diamino-2,5-dimethylbenzene; 1,4-diamino-2,3-dimethylbenzene; 2-chloro-1,4-diaminobenzene; 1,4-diamino-2-(thiophen-2-yl)benzene; 1,4-diamino-2-(thiophen-3-yl)benzene; 1,4-diamino-2-(pyridin-3-yl)benzene; 2,5-diaminobiphenyl; 1,4-diamino-2-methoxy-methylbenzene; 1,4-diamino-2-aminomethylbenzene; 1,4-diamino-2-hydroxymethylbenzene; 1,4-diamino-2-(2-hydroxyethoxy)-benzene; 2-[2-(acetylamino)-ethoxy]-1,4-diaminobenzene; 4-phenylaminoaniline; 4-dimethylaminoaniline; 4-diethylaminoaniline; 4-dipropylaminoaniline; 4-[ethyl-(2-hydroxyethyl)amino]-aniline; 4-[di(2-hydroxy-ethyl)-amino]aniline; 4-[di(2-hydroxyethyl)amino]-2-methylaniline; 4-[(2-methoxyethyl)-aminolaniline; 4-[(3-hydroxypropyl)amino]-aniline; 4-[(2,3-dihydroxypropyl)aminoaniline; 1,4-diamino-2-(1-hydroxyethyl)-benzene; 1,4-diamino-2-(2-hydroxyethyl)benzene; 1,4-diamino-2-(1-methylethyl)-benzene; 1,3-bis-[(4-aminophenyl)(2-hydroxyethyl)amino]-2-propanol; 1,4-bis-[(4-amino-phenyl)amino]butane; 1,8-bis-(2,5-diaminophenoxy)-3,6-dioxaoctane; 4-aminophenol; 4-amino-3-methylphenol; 4-amino-3-(hydroxymethyl)phenol; 4-amino-3-fluorophenol; 4-methylaminophenol; 4-amino-2-(aminomethyl)phenol; 4-amino-2-(hydroxymethyl)phenol; 4-amino-2-fluorophenol; 4-amino 2-[(2-hydroxyethyl)amino]-methylphenol; 4-amino-2-methylphenol; 4-amino 2-(methoxymethyl)phenol; 4-amino-2-(2-hydroxyethyl)phenol; 5-aminosalicylic acid; 2,5-diaminopyridine; 2,4,5,6-tetraamino-pyrimidine; 2,5,6-triamino 4-(1H)-pyrimidone, 4,5-diamino-1-(2-hydroxyethyl)-1H-pyrazole; 4,5-diamino-1-(1-methylethyl)-1H-pyrazole; 4,5-diamino-1-[(4-methylphenyl)-methyl]-1H-pyrazole; 1-[(4-chlorophenyl)methyl]-4,5-diamino-1H-pyrazole; 4,5-diamino-1-methyl-1H-pyrazole; 2-aminophenol; 2-amino-6-methylphenol; 2-amino-5-methylphenol and 1,2,4-trihydroxybenzene.

10. The composition as defined in claim 5, wherein, in addition to said at least one 1,3-dihydroxy-4-heteroarylbenzene derivative, said coupler substance includes at least one member selected from the group consisting ofN-(3-dimethylaminophenyl)urea; 2,6-diaminopyridine; 2-amino-4-[(2-hydroxyethyl)-amino]anisole; 2,4-diamino-1-fluoro-5-methylbenzene; 2,4-diamino-1-methoxy-5-methylbenzene; 2,4-diamino-1-ethoxy-5-methyl-benzene; 2,4-diamino-1-(2-hydroxyethoxy)-5-methylbenzene; 2,4-di[(2-hydroxy-ethyl)-amino]-1,5-dimethoxybenzene; 2,3-diamino-6-methoxypyridine; 3-amino-6-methoxy-2-(methylamino)pyridine; 2,6-diamino-3,5-dimethoxypyridine; 3,5-diamino-2,6-dimethoxypyridine; 1,3-diaminobenzene; 2,4-diamino-1-(2-hydroxyethoxy)benzene; 1,3-diamino-4-(2,3-dihydroxypropoxy)benzene; 1,3-diamino-4-(3-hydroxypropoxy)benzene; 1,3-diamino-4-(2-methoxyethoxy)-benzene; 2,4-diamino-1,5-di(2-hydroxyethoxy)benzene; 1-(2-aminoethoxy)-2,4-diaminobenzene; 2-amino-1-(2-hydroxyethoxy)-4-methyl-aminobenzene; 2,4-diaminophenoxyacetic acid; 3-[di(2-hydroxyethyl)amino]aniline; 4-amino-2-di[(2-hydroxyethyl)amino]-1-ethoxybenzene; 5-methyl-2-(1-methylethyl)phenol; 3-[(2-hydroxyethyl)amino]aniline; 3[(2-aminoethyl)-amino]aniline; 1,3-di-(2,4-diaminophenoxy)propane; di(2,4-diaminophenoxy)methane; 1,3-diamino-2,4-dimethoxybenzene; 2,6-bis(2-hydroxyethyl)aminotoluene; 4-hydroxyindole; 3-dimethylaminophenol; 3-diethyl-aminophenol; 5-amino-2-methylphenol; 5-amino-4-fluoro-2-methylphenol; 5-amino-4-methoxy-2-methylphenol; 5-amino-4-ethoxy-2-methylphenol; 3-amino-2,4-dichlorophenol; 5-amino-2,4-dichloro-phenol; 3-amino-2-methylphenol; 3-amino-2-chloro-6-methylphenol; 3-aminophenol; 2-[(3-hydroxyphenyl)amino]acetamide; 5-[(2-hydroxyethyl)-amino]-4-methoxy-2-methylphenol; 5-[(2-hydroxyethyl)amino]-2-methylphenol; 3[(2-hydroxyethyl)-amino]phenol; 3-[(2-methoxyethyl)amino]phenol; 5-amino-2-ethylphenol; 5-amino-2-methoxyphenol; 2-(4-amino-2-hydroxyphenoxy)ethanol; 5-[(3-hydroxypropyl)amino]-2-methylphenol; 3-[(2,3-dihydroxypropyl)amino]-2-methylphenol; 3-[(2-hydroxyethyl)amino]-2-methyl-phenol; 2-amino-3-hydroxypyridine; 2,6-dihydroxy-3,4-dimethylpyridine; 5-amino-4-chloro-2-methylphenol; 1-naphthol; 2-methyl-1-naphthol; 1,5-dihydroxynaphthalene; 1,7-dihydroxynaphthalene; 2,3-dihydroxynaphthalene; 2,7-dihydroxynaphthalene; 2-methyl-1-naphthol acetate; 1,3-dihydroxybenzene; 1-chloro-2,4-dihydroxybenzene; 2-chloro-1,3-dihydroxybenzene; 1,2-dichloro-3,5-dihydroxy-4-methylbenzene; 1,5-dichloro-2,4-dihydroxybenzene; 1,3-dihydroxy-2-methylbenzene; 3,4-methylenedioxyphenol; 3,4-methylene-dioxyaniline; 5-[(2-hydroxyethyl)amino]-1,3-benzodioxole; 6-bromo-1-hydroxy-3,4-methylenedioxybenzene; 3,4-diaminobenzoic acid; 3,4-dihydro-6-hydroxy-1,4-(2H)benzoxazine; 6-amino-3,4-dihydro-1,4-(2H)-benzoxazine; 3-methyl-1-phenyl-5-pyrazolone; 5,6-dihydroxyindole; 5,6-dihydroxyindoline; 5-hydroxyindole; 6-hydroxyindole; 7-hydroxyindole and 2,3-indolinedione.

11. The composition as defined in claim 5, containing from 0.005 to 20 wt. % of a total amount of said developer substance and said coupler substance, based on a total amount of said composition.

12. The composition as defined in claim 5, further comprising at least one direct dye compound.

13. The composition as defined in claim 5, having a pH of 6.5 to 11.5.

14. The composition as defined in claim 5, consisting of a hair colorant.

15. A composition for dyeing keratin fibers containing a combination of developer substance and coupler substance, wherein said coupler substance comprises at least one 1,3-dihydroxybenzene derivative of formula (Ia), or a physiologicallytolerated, water-soluble salt thereof: ##STR00013## wherein R'1 denotes a substituted pyridyl group, a pyrimidyl group, a group of formula (IIa): ##STR00014## or a group of formula (IIIa): ##STR00015## wherein R'2, R'3, R'4, R'5 and R'6, independently ofeach other, denote hydrogen, a halogen atom, a cyano group, a hydroxyl group, a C.sub.1 C.sub.4-alkoxy group, a C.sub.1 C.sub.4-- hydroxyalkoxy group, a C.sub.1 C.sub.6-alkyl group, a C.sub.1 C.sub.4-alkylthioether group, a mercapto group, a nitro group,an amino group, a C.sub.1 C.sub.4-alkylamino group, a hydroxy-(C.sub.1 C.sub.4)alkylamino group, a di(C.sub.1 C.sub.4)-alkylamino group, a di[hydroxy(C.sub.1 C.sub.4)-alkyl]amino group, a dihydroxy-(C.sub.3 C.sub.4-alkylamino group, a [hydroxy-(C.sub.1C.sub.4)-alkyl]-C.sub.1 C.sub.4-alkylamino group, a trifluoromethyl group, a --C(O)H group, a --C(O)CH.sub.3 group, a --C(O)CF.sub.3 group, a --Si(CH.sub.3).sub.3 group, a C.sub.1 C.sub.4-hydroxyalkyl group or a C.sub.2 C.sub.4-dihydroxyalkyl group, ortwo adjacent R2 to R6 groups form an --O--CH.sub.2-bridge; X'1 denotes sulfur, nitrogen, oxygen, C--R'9 or N--R'8; X'2 denotes sulfur, nitrogen, oxygen, C--R'10 or N--R'8; X'3 denotes sulfur, nitrogen, oxygen, C--R'11 or N--R'8; R'7, R'9, R'10 andR'11, independently of each other, denote hydrogen, a halogen atom, a cyano group, a C.sub.1 C.sub.4-alkoxy group, a C.sub.1 C.sub.6-alkyl group, a C.sub.1 C.sub.4-alkylthioether group, a mercapto group, a nitro group, an amino group, a C.sub.1C.sub.4-alkylamino group, a di(C.sub.1 C.sub.4)-alkylamino group, a di(C.sub.1 C.sub.4-hydroxyalkyl)amino group, a C.sub.1 C.sub.4-hydroxyalkylamino group, a trifluoromethyl group, a --C(O)CH.sub.3 group, a --C(O)CF.sub.3 group, an --Si(CH.sub.3).sub.3group, a C.sub.1 C.sub.4-hydroxyalkyl group or a C.sub.3 C.sub.4-dihydroxyalkyl group; and R'8 denotes hydrogen, a C.sub.1 C.sub.6-alkyl group, a C.sub.2 C.sub.4-hydroxyalkyl group, a phenyl group or an acetyl group, provided that at least one and atthe most two of the X'1 to X'3 groups denote C--R'9, C--R'10 or C--R'11 and at the most one of the X'1 to X'3 groups denotes sulfur, oxygen or N--R'8, and R'1 does not stand for a phenyl group or hydroxyphenyl group.

16. The composition as defined in claim 15, wherein (i) X'2 denotes C--R'10 and X'1 denotes sulfur and X'3 denotes C--R'11 or X'1 denotes C--R'9 and X'3 denotes sulfur, or (ii) X'2 denotes C--R10 and X'1 denotes sulfur and X'3 denotes C--R'11or X'1 denotes C--R'9 and X'3 denotes sulfur and at least one of the R'9 to R'11 groups denotes hydrogen.

17. The composition as defined in claim 15, and wherein said at least one 1,3-dihydroxybenzene derivative is selected from the group consisting of 1,3-dihydroxy-4-(thiophen-2-yl)benzene, 1,3-dihydroxy-4-(5-nitro-thiophen-2-yl)-benzene,1,3-dihydroxy-4-(3-methyl-thiophen-2-yl)benzene, 1,3-dihydroxy-4-(furan-2-yl)benzene, 1,3-dihydroxy-5-(5-chloro-thiophen-2-yl)-benzene, 1,3-dihydroxy-5-(3-methylthiophen-2-yl)-benzene and 1,3-dihydroxy-4-(thiophen-3-yl)-benzene and1,3-dihydroxy-5-(thiophen-3-yl)-benzene.

18. The composition as defined in claim 15, containing from 0.005 to 20 wt. % of said at least one 1,3 dihydroxybenzene derivative.

19. The composition as defined in claim 15, wherein said developer substance is selected from the group consisting of 1,4-diamino-benzene; 1,4-diamino-2-methyl-benzene; 1,4-diamino-2,6-dimethylbenzene; 1,4-diamino-3,5-diethylbenzene; 1,4-diamino-2,5-dimethylbenzene; 1,4-diamino-2,3-dimethylbenzene; 2-chloro-1,4-diaminobenzene; 1,4-diamino-2-(thiophen-2-yl)benzene; 1,4-diamino-2-(thiophen-3-yl)benzene; 1,4-diamino-2-(pyridin-3-yl) benzene; 2,5-diamino-biphenyl; 1,4-diamino-2-methoxy-methylbenzene; 1,4-diamino-2-aminomethyl-benzene; 1,4-diamino-2-hydroxymethylbenzene; 1,4-diamino-2-(2-hydroxy-ethoxy)-benzene; 2-[2-(acetylamino)ethoxy]-1,4-diaminobenzene; 4-phenyl-aminoaniline; 4-dimethylaminoaniline:4-diethyl-aminoaniline; 4-dipropylamino-aniline; 4-[ethyl-(2-hydroxyethyl)amino]aniline; 4-[di(2-hydroxyethyl)-amino]-aniline; 4-[di(2-hydroxyethyl)amino]-2-methylaniline; 4-[(2-methoxyethyl)-aminolaniline; 4[(3-hydroxypropyl)amino]aniline; 4[(2,3-dihydroxypropyl)-aminoaniline; 1,4-diamino-2-(1-hydroxyethyl)benzene; 1,4-diamino-2-(2-hydroxyethyl)benzene; 1,4-diamino-2-(1-methylethyl)benzene; 1,3-bis-[(4-aminophenyl)(2-hydroxyethyl)amino]-2-propanol; 1,4-bis-[(4-aminophenyl)amino]butane; 1,8-bis-(2,5-diaminophenoxy)-3,6-dioxaoctane; 4-aminophenol; 4-amino-3-methylphenol; 4-amino-3-(hydroxymethyl)phenol; 4-amino-3-fluorophenol; 4-methylaminophenol; 4-amino-2-(aminomethyl)phenol; 4-amino-2-(hydroxymethyl)phenol; 4-amino-2-fluorophenol; 4-amino-2-[(2-hydroxyethyl)-amino]-methylphenol; 4-amino-2-methylphenol; 4-amino-2-(methoxymethyl)-phenol; 4-amino-2-(2-hydroxyethyl)phenol; 5-aminosalicylic acid; 2,5-diamino-pyridine; 2,4,5,6-tetraamino-pyrimidine; 2,5,6-triamino-4-(1H)-pyrimidone; 4,5-diamino-1-(2-hydroxyethyl)-1H-pyrazole; 4,5-amino-1-(1-methylethyl)-1H-pyrazole; 4,5-diamino-1-[(4-methylphenyl)-methyl]-1H-pyrazole; 1-[(4-chloro-phenyl)-methyl]-4,5-diamino-1H-pyrazole; 4,5-diamino-1-methyl-1H-pyrazole; 2-aminophenol; 2-amino-methylphenol; 2-amino-5-methylphenol and 1,2,4-trihydroxybenzene.

20. The composition as defined in calm 15, wherein, in addition to said at least one 1,3-dihydroxybenzene derivative, said coupler substance includes at least one member selected from the group consisting of N-(3-dimethylaminophenyl)-urea; 2,6-diaminopyridine; 2-amino-4-[(2-hydroxy-ethyl)-amino]anisole; 2,4-diamino-1-fluoro-5-methylbenzene; 2,4-diamino-1-methoxy-5-methyl-benzene; 2,4-diamino-1-ethoxy-5-methylbenzene; 2,4-diamino-1-(2-hydroxyethoxy)-5-methylbenzene; 2,4-di[(2-hydroxyethyl)-amino]-1,5-dimethoxybenzene; 2,3-diamino-6-methoxypyridine; 3-amino-6-methoxy-2-(methylamino)pyridine; 2,6-diamino-3,5-dimethoxypyridine; 3,5-diamino-2,6-dimethoxypyridine; 1,3-diaminobenzene; 2,4-diamino-1-(2-hydroxyethoxy)benzene; 1,3-diamino-4-(2,3-dihydroxypropoxy)-benzene; 1,3-diamino-4-(3-hydroxypropoxy)benzene; 1,3-diamino-4-(2-methoxyethoxy)-benzene; 2,4-diamino-1,5-di(2-hydroxyethoxy)-benzene; 1-(2-aminoethoxy)-2,4-diaminobenzene; 2-amino-1-(2-hydroxyethoxy)-4-methyl-aminobenzene; 2,4-diaminophenoxyacetic acid; 3-[di(2-hydroxyethyl)-amino]aniline; 4-amino-2-di[(2-hydroxyethyl)amino]-1-ethoxybenzene; 5-methyl-2-(1-methylethyl)phenol; 3-[(2-hydroxyethyl)amino]aniline; 3[(2-aminoethyl)-amino]aniline; 1,3-di-(2,4-diamino-phenoxy)propane; di(2,4-diaminophenoxy)-methane; 1,3-diamino-2,4-dimethoxybenzene; 2,6-bis(2-hydroxyethyl)aminotoluene; 4-hydroxyindole; 3-dimethylaminophenol; 3-diethyl-aminophenol; 5-amino-2-methylphenol; 5-amino-4-fluoro-2-methylphenol; 5-amino-4-methoxy-2-methylphenol; 5-amino-4-ethoxy-2-methylphenol; 3-amino-2,4-dichlorophenol; 5-amino-2,4-dichlorophenol; 3-amino-2-methylphenol; 3-amino-2-chloro-6-methylphenol; 3-aminophenol; 2-[(3-hydroxy-phenyl)amino]acetamide; 5-[(2-hydroxyethyl)amino]-4-methoxy-2-methylphenol; 5-[(2-hydroxyethyl)amino]-2-methylphenol; 3-[(2-hydroxyethyl)-amino]phenol; 3-[(2-methoxyethyl)amino]-phenol; 5-amino-2-ethylphenol; 5-amino-2-methoxyphenol; 2-(4-amino-2-hydroxyphenoxy)ethanol; 5-[(3-hydroxypropyl)amino]-2-methylphenol; 3-[(2,3-dihydroxypropyl)amino]-2-methylphenol; 3-[(2-hydroxyethyl)amino]-2-methylphenol; 2-amino-3-hydroxypyridine; 2,6-dihydroxy-3,4-dimethylpyridine; 5-amino-4-chloro-2-methylphenol; 1-naphthol; 2-methyl-1-naphthol; 1,5-dihydroxynaphthalene; 1,7-dihydroxynaphthalene; 2,3-dihydroxynaphthalene; 2,7-dihydroxynaphthalene; 2-methyl-1-naphthol acetate; 1,3-dihydroxybenzene; 1-chloro-2,4-dihydroxybenzene; 2-chloro-1,3-dihydroxybenzene; .sub.1,2-dichloro-3,5-dihydroxy-4-methylbenzene; 1,5-dichloro-2,4-dihydroxybenzene; 1,3-dihydroxy-2-methylbenzene; 3,4-methylenedioxyphenol; 3,4-methylene-dioxyaniline; 5-[(2-hydroxyethyl)amino]-1,3-benzodioxole; 6-bromo-1-hydroxy-3,4-methylenedioxybenzene; 3,4-diaminobenzoic acid; 3,4-dihydro-6-hydroxy-1,4-(2H)benzoxazine; 6-amino-3,4-dihydro-1,4-(2H)benzoxazine; 3-methyl-1-phenyl-5-pyrazolone; 5,6-dihydroxyindole; 5,6-dihydroxyindoline; 5-hydroxyindole; 6-hydroxyindole; 7-hydroxyindole and 2,3-indolinedione.

21. The composition as defined in claim 15, containing from 0.005 to 20 wt. % of a total amount of said developer substance and said coupler substance, based on a total amount of said composition.

22. The composition as defined in claim 15, further comprising at least one direct dye compound.

23. The composition as defined in claim 15, having a pH of 6.5 to 11.5.

24. The composition as defined in claim 15, consisting of a hair colorant.